By train:
From Milan Stazione Centrale station, you can take a taxi or the underground green line (direction Cologno Nord-Gessate) till Piazzale Loreto stop. Exit the station following the indications to Piazza Argentina. Proceed along Corso Buenos Aires towards the city centre and then turn right into Via Gaspare Spontini, where the hotel is located.
By airplane:
From Milan Malpensa and Linate airports, you can take a taxi or the shuttle bus (Shuttle Express) till the City Air Terminal (Stazione Centrale). Then follow the above indications.